Authors - Domenico D’Uva Abstract - Indoor air quality (IAQ) is a frequently overlooked determinant of health in rural villages, where the extensive use of solid fuels for cooking and space-heating generates elevated concentrations of airborne pollutants. This study presents an integrated, low-cost protocol for improving IAQ in rural dwellings, combining real-time environmental monitoring, simplified digital modelling and passive strategies of ventilation and biophilic design. The methodology can be structured into three steps: Conceptual digital twin, feedback interface, ventilation strategies, biophilic integration. Conceptual digital twin is based on the mapping of each dwelling linked to Arduino low-cost, stand-alone sensors (CO₂, PM₂.₅, temperature and relative humidity) that collect data at temporal resolution of one minute. An immediate feedback interface based on visual and/or acoustic indicators that prompt residents to take corrective actions (selective opening of windows, activation of cross-breezes), when exposure thresholds - derived from WHO Air Quality Guidelines - are exceeded. Data-driven natural-ventilation strategies – optimal ventilation windows identified through time-series analysis of sensor data, calibrated to local weather conditions and occupancy profiles to maximise air exchange while minimising heat losses. Biophilic integration implies the introduction of resilient plant species with proven phytoremediation capacity, as Epipremnum aureum) which could reduce CO₂ level, with quantitative guidance on density (two to three plants per main room) and optimal placement. Using low-cost IoT sensors, the protocol monitors environmental parameters and pollutant concentrations in real time. The system targets specific safety and comfort thresholds, aiming to maintain CO₂ levels below 700 ppm and PM₂.₅ below 50 μg/m³ to optimize occupant health (Wu et al, 2021). These thresholds, derived from World Health Organization (WHO) guidelines, are essential to ensure occupant satisfaction and well-being. The ultimate objective is to define a scalable and replicable intervention model capable of combining digital technologies and natural solutions for the sustainable regeneration of fragile territories.