Authors - Thapanapong Sararat, Ratanachote Thienmongkol, Ruethai Nimnoi, Wongpanya S. Nuankaew, Pratya Nuankaew Abstract - Ensuring equitable access to library information systems is crucial in the digital era, particularly for visually impaired users who rely on assistive technologies. WebOPACs are key gateways to resources, but many remain difficult to use despite referencing accessibility standards. This study proposes a Disability-Centered Framework to improve accessibility and Universal Design in Thailand’s WebOPACs. Developed through design-based research, it integrates international accessibility literature, Universal Design principles, WCAG 2.1, and evaluation insights. The framework emphasizes three components: disability-focused design principles, classification of visually impaired users and needs, and task-specific accessibility requirements across perception, navigation, interaction, and assistive-technology compatibility. It also incorporates Thai linguistic, cultural, and technological conditions to bridge global standards and local implementation. Findings indicate that meaningful accessibility requires iterative testing and ongoing refinement rather than a one-time compliance check. This framework guides libraries, developers, and policymakers in enhancing WebOPAC accessibility and supporting inclusive access for visually impaired users in Thailand.