Authors - Kari Sai Vardhan, Maram Ramakrishna Reddy, Kore Akhil, Modugula Pavan Kumar Reddy, Aaskaran Bishnoi Abstract - This study evaluates the effectiveness of student-led mobile-first web design implementation for Small and Medium-sized Enterprises (SMEs) using the Bootstrap framework. By applying a project-based information system development model, this study analyzes the technical performance of websites, particularly in terms of layout responsiveness and system metrics such as PageSpeed. A mixed-methods approach was used to collect quantitative data from technical evaluations and qualitative data from student and client feedback. The results indicate that these student-led projects successfully produced highly responsive and high performing websites, significantly enhancing the digital presence of SMEs. The findings underscore the pedagogical efficacy of project-based learning in equipping students with industry-relevant competencies and practical skills in information system development, while simultaneously sup-porting the digital transformation of SMEs.